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Homo sapiens (human) Long non-coding antisense RNA CDKN2B-AS1 URS0000732D5D_9606

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CDKN2B-AS1: CDKN2B-AS1, also known as ANRIL, is a long non-coding RNA (lncRNA) located in the genomic hotspot region at chromosome 9p21.3 [PMC8045214]. It has been implicated in various diseases, including thyroid cancer [PMC9772501], endometriosis [PMC8304276], breast cancer [PMC8806778], exfoliation glaucoma [PMC7780652], and kidney renal clear cell carcinoma (KIRC) prognosis [PMC7895987]. CDKN2B-AS1 has been shown to regulate the proliferation and apoptosis of breast cancer cells [PMC8806778]. It is also involved in the regulation of genes such as IGF2BP3, NUF2, HMGA2, and ADAM10 [PMC7895987, PMC9065414, PMC7664438, PMC7184162]. Additionally, CDKN2B-AS1 has been found to interact with miRNAs such as miR-140-5p and miR-217 [PMC8201744, PMC7184162]. It is regulated by transcription factors like ERα and C/EBPβ [PMC7563355, PMC6814794]. CDKN2B-AS1 has been associated with hallmarks of cancer such as genome instability and mutation [PMC7279016]. It may also play a role in cellular senescence and inflammation mediated by TGFβ signaling pathway [PMC7564117]. Furthermore, CDKN2B-AS1 has been implicated in atherosclerosis development and stroke risk in European populations [PMC6461186, PMC7184162]. In various diseases including colorectal cancer (CRC), IPF (idiopathic pulmonary fibrosis), and breast cancer (BC), increased levels of CDKN2B-AS1 have been observed suggesting its role in promoting tumorigenesis or disease progression [PMC8806871, PMC9339643, PMC8045214].

Genome locations

Gene Ontology annotations

Sequence

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AGCUACAUCCGUCACCUGACACGGCCCUACCAGGAACAGCCGCGCUCCCGCGGAUUCUGGUGCUGCUCGCGUCCCCGCUCCCCUAUUCCCCUUAUUUUAUUCCUGGCUCCCCUCGUCGAAAGUCUUCCAUUCUUCAAACUAGAUUAUUUAAAAAUGAAAAAGGAAGAAAGGAAAGCGAGGUCAUCUCAUUGCUCUAUCCGCCAAUCAGGAGGCUGAAUGUCAGUUUUGAACUAAAAGCCGCUCCGCUCCUCUUCUAGAUUUGGAAAACAAGCGAAAUUAAACUAAACCGCUGCACGCCUCUGACGCGACAUCUGGACACGGCGCGGCGCUGGCGCUGCCGGAGCUGUCGACCCGGCCUGGCGCCGGACUAGGACUAUUUGCCACGACAUUUCAAAGGAUUCCAAGAGAGAAUAUUGGUGUCCAUGCUGUGAUGAUUCCUCAGCUCCUCUCAUCUGAUCUCCGUCCUGGCCCCCAUGACUUUCUUUGUGGUAGUUAGGGUGUGGUAUGUGCCACUGAGGCCCACACCUAUUGCUGCAAUUUAUAGCACUGAUCUGUCAUCAAUACCACUUGCUGUCUUGGAUGUGAAGAUGAUUUUUCCUGCAGGGAUUCCCUCUACAAAAUUAAAAACACUGGGCAUGUGGAAAUAAUAUUCAUGCUUUAAAUUGUCUUUUCUCUUCACUACACCAGGGGUCCCCAACCCCUAGGCCACAGACUGUGGCCCUAGUGUAGUGAAUAGAAAAGACAAUUUAAAGCGUGAAUAUUAUUUCCUCAUGCCCAGUGUUUUUAAUUUUGUACUGGUCUGUGGCUUGUUAGAAACCAGGCUGCACAGCAGAAGGUGGGCAGCAGAUAUUGAGAAACCACAGAAAGAGAGAAGUUAAAUAAUUUUCCUGUCAAAGACCACAUCAAUGAUGAAGCCAGAAUUUGAGCUCAUGUACUUAACCACUGGACUACCUGCCUGCCCUGUCGAGGAACAGCUAAGUGUCCCUUUUGAUGAGAAGAAUAAGCCUCAUUCUGAUUCAACAGCAGAGAUCAAAGAAAAGACUUCUGUUUUCUGGCCACCAGAUAUAUGUUAUCUGUGCUUAAAGAAUUGAAAAACACACAUCAAAGGAGAAUUUUCUUGGAAAGAGAGGGUUCAAGCAUCACUGUUAGGUGUGCUGGAAUCCUUUCCCGAGUCAGUACUGCUUUCUAGAAGAAAACCGGGGAGAUCUAUUUGGAAUGUAUCUAACUCCAAAGAAACCAUCAGAGGUAACAGUAGAGACGGGGUUUCACCAUGUUGGCCAGACUGGUCUUGAACUCUCGACCUCGUGAUUCGCCCGCCUCGGCCUCCCAAAGUGCUGGGAUUACAGGUGUGAGACACCACACCCGGCGGAUAGAGAGAAUUUUGACAGUCUCUCCAAUGAACGCCUUCACUGAUAUCCAAAGCAUGAAGGACACACCAGGGAAAAACAUAGACCUAACACAGGACAAAUGGAAUUAUUAGAAACAUUUUCUAGCAGAAGAACACUAUUCUGUUGCCAUUUGAAUCUUUGCUUCUUUCUAGGUUUGACAAUGAGCCUAUCAUAUAAGCCCAAAUGUAAACAGAAAGAGGUUGAAUCAGUCACGAUAAGCCCAAUUAUGCUGUGGUAACAAACAACCUCAAAAUCUCAUUGGCUUAAAAUAUACAGAAUUAUUCUUACUCAUGGCACAUAUCCAUCUAUCAUCUGCAGGGGAUCUGCUCACUGAAGUCACUUAGGAACUUGGACUGAUGGAACGGCCACUUUUUGGUCACUAUAUGUAUUAAUCUGUUUUAAUCCUGCUGAUAAAGACCCAAAAUUGGGAACAAAAAGAAGUUUAACUAGACUUACAGUUCCGCAUGGCUGAGGAGGCCUCAGAAUCAUGGUGGGAGGCGAAAGGCACUUCUUACAUGGUGGCAGCAAGAGAAAAAUGAGGAAGAAGCAAAAGCGGAAACCUCUGAUAAACCCAUCAGAUCUUAUGAGACUUAUUCCACUAUCAAGAGAAUAGCAUGGGAAAGACUGGCUCCCAUAAUUUACCUCCCUCUGGGUCCCUCCCUCAACAUGUGGGAAUUCUGGGAGAAACAAUUCAAGAUAUGACACAUUCAUAAUUUAAACAGAAGCCUACGAAGAACUCAUAAAUUAAAAGAAGAUAAUCUUUUCACAAGGUGAUGGAGGCUUUUUAUUUUGCCACAAAACCACUGGUGACGUUGCCUGUGGCCACCUUGGAGAAGACACUGGAGGCCUGGGACAUGGAGACUGCUUUUCUGCAGAAACCACAUCCCUUGGAGUAAUGAGCUACACCUACCUCAAUUAUUCAGUGCAGUACAACACUCCAGACAGGGUCUCACUCUGUCACCCAGGCUGGAGUGUAUUGGCAUGAUUACAGCUCACUGCAACCUUGAACUCCCAGGCUCAAACCUGAGCAGCUGGGACUACAGAUGCACCACCAUGCAUGGUACCAGAGAUAUAAUAAUGAGAAACAGACAUGCUCCCUCCCCUCAUUGAGGUUACAGCUUAGUGUGGAGACACACAGAUGCCUAACGCACUAUGGUAUGGAAGGUGCUAUGGACACAGUGCUCAAAUCCAUGAUCUACAUAGGUGGAGAACUUCAGUAGAGGAAGUGGCAGGAAUUUGGGAAUGAGGAGCACAGUGAUUAAACUGGGGCCAUUCAUAUGAGAGUUUAAGAACUCAGACCAGUGACUUAGAUUGGCUUCUCUCACAUGGCAAGAAACAUUGCUGCUAGCACUUCCCGAGUUCUACGUUCUACAACAUCCACCACUGGAUCUUAACAUAGACGUAAGAUCAAAUGCAAUAGCAUGUCAAACAAUGUGUAACUCCAGUUAUACAAACAUUACUGUAUCUCAUUGGGGAUACGAAGCUCUACACACUUGAAGAUGGUGAAGGAAUAUAAAAAUCUAUGUCUCACAGUCCAGACUUGGAGUACAAGUAAUAAGAAGAAUAAAACUUAAUCCCUUAAGUAGAUUCACCAUAAGUUAGCUCAGAGCAAUUCCAGUGCAAGUAUGGUCUGUGAUCCAGUAGUAUCUUACAGACAGCAAGUUGAACAUUGUGGGAUGCAUGAGCUAUUGAGGCCUUUGCAGCUUUCUGCUACAUGGAGGCUAGGGCCAGAGUCAAGAUUUAUGCUUUGCAGCACACUGGUCAGCUGUUUUUGCAAAUCAGAUUAAAUGAUUUUUAAAUGAGGCUGAGAGCAUGGGAGAUACUAAUGUGUGUUUCCUUGUGAGCUACUGCAUAAGUUAGGAAAUUGAAAUACAGAAAGAUGAAAAGUGAUUUGCCCAAGCAUAUAGAUCAAAGCUGUGGCAGAACCAGGACUGGAACCUAUAUCUCUCUACUAAUGGUUUUUUUAAAAAAAUAACCUUGUUUCAAAAAUAUUAAAAAGUCACAAGAAAGGUAAACAUGUGGAUAAACAAAAUGAAGAAAAUAAAAAUUAUCCAGUAAUAACAUAUUGGCAUAUGUCUUUCUGGUAUAUUUUCCUGUGUUGUCAUCAUUAUCAUCUCCAUCAUCAUUAUAUCCAUCAUUAUCAUCAUCAUCAUCAUCAUCAUCAUCAUUAUCAUCACCAUAGUGAACAUGUAAUGCUUACCUAGUGCCAGAUGCUGUCUAGGCAUUUUACAUGUGUUACUGGUAACUCAUGUAAUCCUCAUAACAACCUUAUAAGGUGGUUGCUAUUAUCCCCAUGUUACAUAUGAAGAGACAGAAGCAUAAAGAAGUUGCACCGCUGGUAAUUGGCUGGGAUUUGAACUUAAGCAGUCUAACCUUAGAGUAAUGAUUUUAACAACUAUGCUAUAUACAUACAAAUUUACAAAAUAAAACUGGGCUCAGACAAUAAAAAAAAAAAAAAAAAAAAAAAAA

Taxonomic tree

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Publications