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Homo sapiens (human) PAX6 upstream antisense RNA (PAUPAR) URS0000732D2A_9606

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PAUPAR: PAUPAR is a long non-coding RNA (lncRNA) that has been implicated in various cellular processes and diseases. In HCT116 cells, knockdown of PAUPAR resulted in repression of ZNF750 expression, which was partially reversed by miR-17-5p inhibition. Conversely, overexpression of PAUPAR in HCT8 cells increased ZNF750 expression, which was counteracted by miR-17-5p overexpression [PMC8806802]. PAUPAR has also been found to be dysregulated in uveal melanoma cells and is associated with cell proliferation, colony formation, invasion, migration, and tumor metastasis [PMC6738428]. Knockdown of PAUPAR disrupted the normal cell cycle profile and enhanced neuronal differentiation in neuroblastoma cells [PMC5491930]. Additionally, PAUPAR was found to function as a trans-acting transcriptional regulator by binding to genomic locations distal to its own locus [PMC3983687]. It was also shown that KAP1 and PAUPAR co-occupy a binding site within the Ezh2 gene [PMC5978383]. In the developing cerebellum, PAUPAR is expressed in both the internal and external granular layers where Pax6 is also strongly expressed [PMC3983687]. High-resolution NG Capture-C analysis revealed chromatin interactions between PAUPAR and Pax6 promoters as well as cis-regulatory DNA sequences important for their expression control in neuronal cells [PMC9202886]. Furthermore, motif discovery identified a motif resembling a known PAX6 DNA binding motif at some of the top scoring PAUPAR binding locations [PMC3983687].

Genome locations

Gene Ontology annotations

Sequence

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AAAGGUACCGGAAUAAAAAUUUGACUAAAGUUUGGGAUAAAUUAAUCGGUGGCUUGAAGAACAGUAGCACAUUUCUGAUUAUGUAGGCUCCAGCCAGGAUUUAAGUUUUGUGUCAUGAUUGUUUUCAUAUUUCUUUGACAUCUAUUGAUUUGGAGGCAGCUGCAAGCCUUUGUCACAGGAGAGAAGAGCAGUCACAAUAUAUUAGCUUGAUGGCAUAACUCGAACCGGAGAAGCGAGGGGAGCCUGAGUGACUGGGGCGCACAUGACCCCCCUCCUGGGGCCUUUGGGCUCAACCCUUACUUUUAACUUGUUCUAACAGGAAUAAUGGAGUAGUACUACUAAUGCAUGGUCAGAAGGGGCUUUUCUGUCUAGAACGCAGGCGGCGGGAGUUGCACCGCCACAGCCCGGGAGACCAAAGAGUCUCCACUCCCCGCUCCCGGCGCCUCCUCGCCGACCGGAGCCCCGAGCCCAGUGAGCCCAGCCGGUCCCACGUCGAGAGGCGCUGGGUUGGGAGAAGUUCUGCUGGUCGUGGGCUCGGCCCCCAGGCGCCAGGCCGAGUGCCCACCUCGGCUUCUUUAGGGGGCCUACAGCGGGCAGCCGAGCGGCUGGCGGACCCGGAGCUUGGGAGGCGACCGCCAGGCUGGUGCCCGGCCUGACCCGGCGUUCGCGGCCGCCCGCUCGCCCGCCGCGGGCCGGGAGCGUACAGGAGUGUGACGCAGAUUGUGAAAACAGAAGGGAGGGAGUUGGGUCAUUUCCUUCGCUAAUCAUCGCCCCCUCCUGCUCCUCCUCCCCACCCCCAUCCCAUCCUCGCCGCCACCCAGCCUCGAACUCUCUUCCUUGCCAGAGUCUGCCUCACUUUGAGCCAGUGGCUGCACUUUAUGGAGAAAAUAUAUGUGCCCAUCACUCACCCAUCUAUUUGCAGCGUCCAUGGAGCGCCUCGGGGAACACGCAUGGACAAUUAAACACACCCACUUACGGCGGGAUGAUGAGGCUUUCUGUUAACCACAUGUGUUCAGAAAUGGAUACAGCCCUAAUUUUGACACGGAAUGCAGCUAAUGCACCUUGCUAUAGAUGUACGUCCGUUGGAAAAGUGUGUGAUGGGCACCUGAUCUACACCAAGAGAACAGGGCUGUCUGCAGAAGACCCAGCGGCCUGACACCUUUUCUUGUUGCCGGGGAAGGAAAGUUUUUCUUUUGAUUUGUCCUCUCACGAUUUUUCCCUUUUCCUUUGCAUUACAGUUUCAGAGAGGAAUGUAAAUAUUUUGACUAGACCUCUGCAGGGGCCUUUUAAACACCAGGCACAAUCAUCUGUGGAAUACUGUAGUUCAUACUUUCAAAACUUGGGUGUUAAAGAGUCUGUCUUGCUGAGGAAACCCAUAGAACUAGUGGCGACCUUUCAACUCCCUAUUUGUGUGAUGAAAUGAAGUAUGCCCUAGUGAUUGUCGAAUUUUAAGGACUUGUUCUGUCACUGCUACUUUCCGAUCGUUUGCAGGGAAGAAAAAUCAAUCAAACAGACCUUUGAUGGGGUUGUGGCAAGGUCACAUUUCACUGUGCUCCAGGCUUACCUCUUCUUAACGCCCCUCCCUGCUGUGGAGCGUGUGCAGGUAGUAUGCAAAACUCUAGAAAUAAUAUUUGAAAAAAUUAACACCUUGUUUAUCUCUUCUGUGUAUUUGAUAUAGGGGUUUCUUUCUUUUCCUGUUUUGGUGUUUAAUACAAGGCUGAUAUAUUGGAACAGAAUGCAGACUUCAAAGAAACUAAAAUUAGGAGGCAAAUAGCGUCAAGGUUUCCUCGGUUUCUGUAUGUAGUACAAAUAGUAUAGCGUCUUUUCAUCCAAAAAGAAGCAAAAAUUGCCAGGAGGCAUAAAGCAUCUCUGAAUAUCCGUUUUUUUUAAAGAAACAAACAUUUCCCAAAUAUUGAUGUACGCAUGGUUUUAUAGUCUGAAAAUAUUUCUAGGCACAAAUAUGGCAUACAAACAUUCGUUUCAACUCUGUCGUUGUUGUUAAAAUGACAGUAAAUUAUAGUUUAUUUUAAGAUACCUCCCUGUUAAUGUCAGUUGAGGUUAUUUUAGGGCCUGGAUGCUCUAGGAAGACCACCUAAAAUGUGUUUAUUUCUCUGCCCAAUUCACCUAUAGUGUAAGGAGCAUUUUAUUUUAUUUUAUUUUAUUUUAUUUUAUUUUAUUAUACUUUAAGUUUUAGGGUACAUGUGCACAAUGUGCAGGUUUGUUACAUGUGUAUACUUGUGCCAUGUUGGUGUGAUGCACCCAUUAACUCGUCAUUUAGCAUUAGGUAUAUCUCCUAAUGCUAUCCCUCCCCUCCCCCCAUCCCACAACAGUCCCCAGAGUGUCAUGUAAGGAGCAUUUUAAAUAAAAUAUUUUGGGCAUCCUUAAGUCCUUUUUUAAAAAUCCAACAUUCUACAAUUGUGACAAAUAGGCUGAAAAAUUUUGUUUUGUUUAUACCAAAUUCAUUUUAAUAAAGCAUUUGCUGAGAUUUUAAUACAACAAAUGCCAACAAAAUGCAUCAGAGUAGAAAAAAGAAAAUAUUUUCAGAAUUGCCUAUAAUAUUGCUUGUGAUCCUAAAUUUUUUGAUGCAAGGAACUUGAAUUUUUCAGCUAAUAUUAUUCUGUUUUCUUAUUCUGUGUUUCUAUUAGAACACUCACCUAUGCUCUGCUUCCCUUGCUGUCUUCCCAUAGCUUAUGUGUGCACUAUGAAUUUCAAUAAAUAUAAAUUACUGCUUAAAAGAAAAAAAAAAAAAAAAAA

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