MIR505: MIR505 is a microRNA that has been studied in various contexts. It has been used in the 2−ΔΔCT method to normalize gene expression [PMC6352865]. MIR505 is particularly amenable to detection in human fluids [PMC6281605]. In the context of Parkinson's disease (PD), MIR505 has been found to be down-regulated in cerebrospinal fluid (CSF) and brain tissue of PD patients [PMC6115491]. It has also been implicated in ovarian aging, as its expression was induced in both mice and humans [PMC9918015]. MIR505 is involved in various biological processes, such as neural tube formation and cell growth, by targeting genes like fibroblast growth factor 18 (FGF18) and mitogen-activated protein kinase kinase kinase 3 (MAP3K3) [PMC7040864]. Altered expression of MIR505 may be associated with spina bifida and neural tube defects [PMC7040864]. Additionally, MIR505 has been found to be up-regulated along with other miRNAs like miR199a/b and miR320, leading to decreased sensitivity to cisplatin and OXA through modulation of the Wnt/β-catenin pathway [PMC9331520]. The location of MIR505 is upstream of the gene that encodes the ATP11C protein [PMC4561498]. In wheat, MIR505 is one of the miRNAs that could not be detected using Northern blot analysis but was validated by semi-quantitative RT-PCR [PMC2394755].