MIR488: MIR488 is a microRNA that has been identified among the differentially expressed genes in various studies [PMC4052096]. Leptin treatment has been shown to decrease the levels of MIR488 in mHypoA-POMC/GFP culture [PMC6947463]. There is evidence to suggest that MIR488 may interact with ZIP and modulate MMP-13 activity [PMC3706240]. Additionally, MIR488, along with other microRNAs such as miR30a, miR9, miR1249, and miR497, has been found to inhibit epithelial-mesenchymal transition (EMT) through MAPK signaling [PMC7602903]. A recent study has reported a relationship between MIR488 and ZIP8 in osteoarthritis, where reduced degradation of chondrocytes was observed [PMC3934988]. The roles of zinc uptake transporters like ZIP8 and MIR488 may be crucial in bone health as low bone mineral density is a common symptom of type 1 and type 2 diabetes [PMC3934988]. However, the epigenetic effect of intermittent hypoxia on the amount of MIR488 has not been confirmed yet [PMC3934988]. In Helicobacter pylori-infected gastric cancer tissues, both miR-218 and MIR488 were found to be decreased but there was no significant difference between different H. pylori strains [PMC6365042]. References: - PMC4052096 - PMC6947463 - PMC3706240 - PMC7602903 - PMC3934988 - PMC6365042