SNORA50C: SNORA50C is a small nucleolar RNA, H/ACA Box 50C, with an unknown function [PMC6232700]. In neuroblastoma cells, SNHG25 promotes the accumulation of SNORA50C and the assembly of the associated small nucleolar ribonucleoprotein (snoRNP) through pseudouridine synthase 1 (DKC1), which ultimately promotes the growth and migration of neuroblastoma cells [PMC9700476]. The co-occurrence of IQGAP2 genomic alterations and deletions in SNORA50A, SNORA50C, and RNA component of 7SK nuclear ribonucleoprotein (RN7SK) genes is associated with reduced disease-free survival in prostate cancer [PMC7336766]. The co-changes in IQGAP2, SNORA50A, SNORA50C, and RN7SK genes may be developed into a diagnostic tool for prostate cancer recurrence [PMC6232700]. There were no SPOP mutations and copy number variations for SNORA50A, SNORA50C, and RN7SK in the MSKCC cohort [PMC6232700]. In neuroblastoma cells, SNHG25 positively regulates the expression of SNORA50C to stabilize HDAC1 protein and promote neuroblastoma development [PMC9276775]. The interaction between DKC1 and SNHG25 facilitates the accumulation of SNORA50C to stabilize HDAC1 protein in neuroblastoma cells [PMC9276775]. Knockdown of either SNHG25 or SNORA50C leads to increased ubiquitination levels of HDAC1 protein in neuroblastoma cells [PMC9276775]. Overall, these findings suggest that the interaction between DKC1-SNHG25-SNORA50C plays a crucial role in promoting malignant behaviors in neuroblastoma through HDAC1 stabilization.