SNORD9: SNORD9 is a small nucleolar RNA C/D Box 9 that is found to have high connectivity in coexpression networks, suggesting its potential role in the development and progression of liver hepatocellular carcinoma (LIHC) [PMC7235675]. In addition to SNORD9, other genes with high connectivity in these networks include CRHBP, CLEC1B, GDF2, and OR5L2 [PMC7235675]. SNORD9 is also among the top downregulated genes involved in membrane depolarization during cardiac muscle cell action potential [PMC10046396]. In the TCGA-LAML study, SNORD9 is one of the genes for which gene expression levels were collected and analyzed [PMC10046396]. Furthermore, SNORD9 is among the upregulated genes in pediatric AML cohort (TARGET-AML) [PMC10046396]. Normalization to endogenous control genes such as SNORD9 was performed to correct for potential RNA input or RT efficiency biases [PMC7801461]. In recognized clusters of genes with common functions, SNORD9 was found to be upregulated along with other small nucleolar RNAs (snRNAs) and downregulated genes involved in cholesterol homeostasis [PMC6839856]. References: - [PMC7235675]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235675/ - [PMC10046396]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10046396/ - [PMC7801461]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7801461/ - [PMC6839856]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6839856/