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SNORD10: SNORD10 is a C/D box small nucleolar RNA (snoRNA) that guides the methylation of specific target sites in RNA molecules [PMC5027482]. It forms the first base pair of Helix 71 in domain IV together with C3787, which is also fully methylated [PMC5027482]. The expression of SNORD10 is reduced in hepatocellular carcinoma (HCC) tissues [PMC7093170]. Knockdown of SNORD10 attenuates the growth of gastric cancer cells [PMC8677010]. SNORD10 is one of the 14 nucleolar box C/D snoRNAs that do not vary in abundance between parent and knockdown cells, regardless of whether 2'-O-methylation of their target residue varies or not [PMC8336889]. SNORD10 targets one of the three examples of 2'-O-methylcytidine within spliceosomal RNA U6 [PMC6894857]. The expression levels of SNORD10 are up-regulated in formalin-fixed paraffin-embedded tissues [PMC7812721]. Additionally, SNORD10 has been identified in plasma samples from healthy individuals [PMC5772623].
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