hsa-mir-668: Hsa-mir-668 is a microRNA that has been studied in various contexts. RT primers and TM primers for hsa-mir-668 were obtained from Applied Biosystem's TaqMan [PMC6208663]. It has been found to interact with the promoter of the AQP4 M1 gene, along with other microRNAs [18 [PMC6208663]. In a specific study, hsa-mir-668 was found to be upregulated, along with hsa-miR-374b-3p, while hsa-miR-370 was downregulated [PMC4222942]. The relationship between hsa-mir-668 and leukemia is uncertain, as it is not clear if it is related to the disease [PMC7929672]. The CD SNP rs7559479 in the IL18RAP locus affects the binding efficiency of hsa-miR-140-3p, hsa-miR-212, and hsa-mir-27a. Another SNP in the same area (rs7603250) affects the binding of hsa-mir-668 [PMC3410018]. Hsa_mir_668 has been identified as one of several microRNAs that can target a validated circRNA called hsa_circRNA_102488 [PMC7063791]. Additionally, it has been found that five survival-associated microRNAs (hsa-miR7705p, hsa_mir_541,hsa_mir_485_3p,hsmiR656,andhsa_mir_668) are encoded in the chromosome 14q32 region [PMC4278335]. HsmiR 154,hsmiR300,hsmiR654,hsmi R665,andhsmIR 668 are not conserved in equids[PM6302407].

MIR668: MIR668 is a conserved vertebrate locus that belongs to a supercluster of many tens of miRNAs [PMC3431481]. In a study investigating the effect of miR185 and MIR668, miR20b was used as a supplement to ensure the same amount of total miRNA in each sample [PMC4591293]. The study also involved cotransfecting luciferase reporter constructs with β-galactosidase plasmid and miR185 and/or MIR668 using Lipofectamine 2000 [PMC4591293]. Another study elucidated the molecular mechanisms of MIR668 in the protection of the kidney during ischemia, suggesting its potential as a therapeutic agent [PMC8001091]. In terms of non-protein coding RNA expression, MIR668 was found to be down-regulated in females but up-regulated in males, along with other snoRNAs, miRNAs, and lncRNAs [PMC7663125]. The reannotation of MIR668 provided evidence for 3'-tailed mirtrons in vertebrates [PMC3431481]. Furthermore, down-regulated expression was observed for MIR668 in various comparison groups [PMC6911042]. References: - PMC4591293 - PMC8001091 - PMC7663125 - PMC3431481 - PMC6911042