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SNORA78: SNORA78 is a small nucleolar RNA (snoRNA) that has been implicated in the tumorigenesis of non-small cell lung cancer (NSCLC) [PMC8319719]. It has been reported that SNORA78, along with SNORA47 and SNORA68, can accurately predict the overall survival of NSCLC patients [PMC6629867]. These three snoRNAs have the potential to serve as prognostic markers for NSCLC patients [PMC7140444]. In addition, SNORA78 has been shown to promote tumorigenesis in NSCLC both in vitro and in vivo [PMC8017274]. It can induce cell cycle arrest in NSCLC cells through upregulation of CDK2 [PMC8017274]. Furthermore, SNORA78 is not associated with mRNA 3′ processing complex and does not affect mRNA 3′ processing efficiency [PMC5587809]. Studies have also identified SNORA78 as part of a snoRNA-based model for predicting overall survival in lung cancer patients [PMC6629867] and as a potential marker for early detection and prognostication of NSCLC [PMC9198423]. However, it should be noted that most risk assessment models based on snoRNAs expression are not validated in clinical cases [PMC9005336].
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