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hsa-mir-567: Hsa-mir-567 is a microRNA that has been found to be downregulated in breast cancer (BC) [PMC5241340]. It is also associated with rectal neoplasms, colorectal neoplasms, and colonic neoplasms [PMC9618768]. Hsa-mir-567 has been identified as a target of the gene importin alpha 3 (KPNA4) and is involved in the regulation of p53 stability [PMC4035288]. In the context of Alzheimer's disease (AD), hsa-mir-567 has been found to be upregulated in patients with mild cognitive impairment (MCI-AD) compared to AD patients and healthy controls [PMC7515963]. It has also been identified as a potential biomarker for AD-related cognitive decline [PMC7515963]. Hsa-mir-567 is mainly expressed in neuronal cells and its dysregulation affects genes involved in neuronal differentiation and brain connection maturation [PMC7515963]. In addition, hsa-mir-567 has been found to be mutated at high frequency in colorectal cancer cell lines and primary tumors, particularly those with microsatellite instability (MSI) [PMC3279428]. Overall, hsa-mir-567 plays a role in various diseases and may have potential diagnostic or therapeutic implications.
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