MIR1275: MIR1275 is a functional microRNA coding gene that has been linked to coronary atherosclerosis [PMC7123062]. It has also been directly reported to participate in multiple sclerosis (MS) [PMC6871504]. In addition, probe cg03903398 targets MIR1275, making it an effective microRNA coding gene [PMC6871504]. MIR1275 is one of the four miRNAs that were found to be downregulated in a study on T1D patients, suggesting its involvement in immune regulation and beta cell function [PMC7989380]. Another meta-analysis of studies on T1D patients also identified MIR1275 as one of the miRNAs involved in immune regulation and insulin processing, suggesting its potential as a biomarker for T1D [PMC6768498]. Furthermore, MIR1275 has been found to be negatively correlated with mitochondrial membrane potential (MMP) suppression and associated genes [PMC8327461]. It has also been reported to be dysregulated in certain types of cancer and infection [PMC5865775]. Lastly, E6 stabilizes RACK1 through O-GlcNAcylation at Ser122 and inhibits MIR1275, which inhibits the LGALS1 gene that encodes galactin1, promoting tumor invasion and metastasis [PMC10006576]. References: - PMC7123062 - PMC6871504 - PMC7989380 - PMC6768498 - PMC8327461 - PMC5865775 - PMC10006576