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MIR378A: MIR378A is a small RNA molecule that has been found to be positively correlated with age, along with miR-34a and miR-320b, and negatively associated with age, along with miR-20a, miR-30b, miR-106b, miR-191, miR-301a, and miR-374a [PMC6196565]. The UCCU sequence of RNA has been chosen for analysis due to its presence in small RNAs such as miR23a, MIR378A, and miR344 [PMC6004406]. MIR378A has been found to be downregulated in the sperm of fathers with high paternal depressive symptoms compared to fathers without such symptoms [PMC8157381]. Additionally, MIR378A has been detected in extracellular vesicles (EVs) during the differentiation of human embryonic stem cells into cardiac cells [PMC7912193]. EVs have been shown to contain several other microRNAs (miRNAs) along with MIR378A [PMC7912193]. The levels of primary MIR378A have been determined using quantitative real-time polymerase chain reaction (qRT-PCR) along with 18 s rRNA [PMC8393456].
References:
[PMC6196565] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196565/
[PMC6004406] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004406/
[PMC8157381] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8157381/
[PMC7912193] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7912193/
[PMC8393456] - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8393456/
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