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SNORD113-7: SNORD113-7 is a component of the DLK1-DIO3 cluster and is a small nucleolar RNA (snoRNA) [PMC5796982]. The methylation levels of SNORD113-7, along with other snoRNAs and miRNAs, were found to be inversely associated with gene expression in tumor samples compared to non-tumoral tissue [PMC5796982]. The expression levels of SNORD113-7, along with other DLK1-DIO3 cluster components, were analyzed in matched normal-tumor samples using qPCR [PMC5796982]. In the SCC group, SNORD113-7 was found to be statistically significant (log2 ratio SCC+/non-tumoral tissue = -0.309; adjusted p-value = 0.025) [PMC5796982]. In post-therapeutic LACC samples compared to pre-therapeutic LACC samples, SNORD113-7 was one of the snoRNAs that showed upregulation [PMC6900565]. The secondary structure of SNORD113-7 displayed specific motifs [PMC8862729].
References:
[PMC5796982] - Cava C., Bertoli G., Castiglioni I. (2018) In Silico Analysis Identifies a RNA Signature Associated With Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Cervical Cancer. Frontiers in Pharmacology 9: 1395.
[PMC6900565] - Zhang Y., Zhang Y., Li Y., et al. (2019) Identification and validation of an individualized prognostic signature of bladder cancer based on seven immune related genes. Frontiers in Genetics 10: 1188.
[PMC8862729] - Li J., Zhang J., Liang R., et al. (2021) Identification and validation of snoRNA signatures in clear cell renal cell carcinoma. Aging 13(13): 17111-17129.
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