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Homo sapiens (human) microRNA hsa-mir-934 precursor URS00006AA21F_9606

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MIR934: MIR934 is a microRNA that has been studied for its role in various biological processes. One study found that a single nucleotide polymorphism (SNP) in MIR934, specifically n.15T>G in the 1st nucleotide in the 5p strand, resulted in altered DROSHA/DICER1 cleavage sites and the generation of a novel miRNA called isomiR [PMC9708458]. To validate the bioinformatics data for target prediction, luciferase assays were conducted to assess the interaction between MIR934 and two target genes, TFCP2L1 or RAB3B [PMC7295570]. In silico analysis and dual luciferase assays confirmed that MIR934 binds to specific sites on the 3'-UTR of FZD5, TFCP2L1, and RAB3B [PMC7295570]. The binding sites of MIR934 on FZD5 were found to be conserved across different species [PMC7295570]. Co-transfection experiments confirmed the binding of MIR934 to these target mRNAs [PMC7295570]. In another study, miR-934 knockdown was achieved using a MIR934 inhibitor to investigate its effect on cell proliferation and cell cycle in colorectal cancer (CRC) cells [PMC8809948]. The levels of circRNF10 and MIR934 were measured using specific primers [PMC9739140]. These findings highlight the functional significance of MIR934 and its potential role in various biological processes.

Genome locations

Gene Ontology annotations

Sequence

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AGAAAUAAGGCUUCUGUCUACUACUGGAGACACUGGUAGUAUAAAACCCAGAGUCUCCAGUAAUGGACGGGAGCCUUAUUUCU

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This sequence is found in 3 other species

Publications