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MIR523: MIR523 is a miRNA gene that is part of the C19MC miRNA gene cluster on chromosome 19 [PMC6193703]. In breast invasive carcinoma, the expression of MIR523 was not significantly different between the CAA and control groups when using a variable threshold, but became significantly different when using a fixed threshold [PMC7157974]. Additionally, MIR523 was close to being significantly different in other analyses [PMC7157974]. However, the targets for MIR523 and other miRNAs in the C19MC cluster could not be predicted due to limited available sequences in databases [PMC2394755]. In hepatocellular carcinoma (HCC), the expression of MIR523 and other C19MC miRNA genes was analyzed using TCGA miRNA-seq dataset and matched to HCC-iCluster RNA-seq data set to create an integrated dataset [PMC7378193]. Furthermore, MIR523 is part of a subset of miRNAs on chromosome 19 that have been associated with stem cell biology and tumorigenesis [PMC8508841].
References:
- [PMC6193703]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6193703/
- [PMC7157974]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7157974/
- [PMC2394755]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394755/
- [PMC7378193]: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378193/
- [PM8508841]: https://www.ncbi.nlm.nih.gov/pmc/articles/PM8508841/
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