SNORD88: SNORD88 is a small nucleolar RNA (snoRNA) that has been implicated in joint aging and osteoarthritis (OA) [PMC5333149]. In joint aging, SNORD88 was found to be significantly decreased in old equine cartilage and human-derived samples [PMC5333149][PMC6769748]. It was also observed that SNORD88 is not differentially expressed in sham versus DMM joint [PMC5333149]. SNORD88 belongs to the LSU snoRNA family and is involved in directing a modification in the H67 region of the 28S rRNA sequence [PMC4288182]. Additionally, genes within the SNORD88 family are associated with splicing regulation [PMC5454292]. In terms of functional effects, SNORD88 has been found to have a segment called the M-box, which displays high complementarity to endogenous pre-mRNA sequences [PMC7038934]. Knocking out endogenous SNORD88C or substituting it with mutated variants would provide a means to investigate the biological significance of M-boxes [PMC7038934]. Overall, snoRNAs such as SNORD88 have shown potential as novel biomarkers for joint aging and OA, highlighting their importance in understanding these conditions [PMC5333149][PMC6769748][PMC4288182][PMC5454292][PMC7038934].