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SNORD1C: SNORD1C is a type of small nucleolar RNA that has been found to be highly expressed in ALDH+ tumor cells in non-small cell lung cancer (NSCLC) [PMC9010412]. This high expression of SNORD1C in ALDH+ tumor cells is associated with a poor prognosis [PMC9010412]. This suggests that SNORD1C may play a role in promoting malignant tumors and may be closely related to tumor cell self-renewal and cancer recurrence [PMC9010412]. In addition to NSCLC, the role and clinical significance of SNORD1C have also been studied in patients with colorectal cancer (CRC) [PMC8806983]. In these studies, SNORD1C expression was analyzed in serum samples from CRC patients using qRT-PCR, and its clinical implication was evaluated in combination with CEA (carcinoembryonic antigen) levels in the blood [PMC8806983]. Furthermore, experiments using SW620 cells with stable transfer of sh-SNORD1C and HCT116 cells overexpressing SNORD1C were conducted to study the effects of altering SNORD1C expression on sphere formation [PMC9010412]. These studies provide insights into the role of SNORD1C in different types of cancer and its potential as a biomarker for prognosis and treatment response.
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