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SCARNA21: SCARNA21 is a computationally predicted H/ACA box snoRNA that contains conserved C and D box elements and is enclosed by a terminal stem structure [PMC4053766]. The elongated isoform of SCARNA21, which is an H/ACA box snoRNA embedded in a C/D box snoRNA, was found to have three additional functional ASEs [PMC4914119]. These findings suggest that SCARNA21 plays an important role in the maturation of snRNAs of the minor spliceosome [PMC4914119]. The sequence inferred from small RNA sequencing data for SCARNA21, SNORD11B, and SNORA58 differed considerably from the sequence defined by the HGNC [PMC4914119]. In samples from patients with type 1 diabetes (T1D), SCARNA21 was found to be up-regulated compared to non-diabetic (ND) samples, while 10 other genes were down-regulated in T1D samples [PMC5952354].
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