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SNORA11B: SNORA11B is a small nucleolar RNA (snoRNA) that has been identified as a potential prognostic and therapeutic target in ovarian cancer [PMC10050728]. It is part of a signature of nine snoRNAs (SNORA11B, SNORA36C, SNORA58, SNORA70J, SNORA75B, SNORD105B, SNORD126, SNORD3C and SNORD89) that have been found to be downregulated in tumor tissues compared to normal tissues [PMC9119353]. The expression of these snoRNAs was tested in clinical tissues and found to be significantly decreased in tumor tissues [PMC9119353]. Additionally, the expression of snoRNA11B has been shown to have high accuracy for the identification of cholangiocarcinoma (CCA) versus primary sclerosing cholangitis (PSC) [PMC7140677]. Furthermore, a signature based on nine snoRNAs including snoRNA11B has been developed to predict the prognosis of ovarian cancer patients [PMC10001105]. The gene for snoRNA11B is located near other genes such as CALM1, NRDE2, PSMC1, RPS18P2 RPS6KA5 RNU7-30P C14orf159 on chromosome 14q32.11 [PMC5264598]. Overall, these findings suggest that snoRNA11B may play an important role in ovarian cancer and could potentially be used as a prognostic marker or therapeutic target.
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