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MIR584: MIR584 is a microRNA that has been found to be upregulated in the liver [PMC4482373]. It is also involved in pancreatic neuroendocrine tumors (pNETs) and pancreatic ductal adenocarcinoma [PMC9554633]. Other miRNAs identified in pNETs include miR1285, miR550a-5P, and miR1825 [PMC9554633]. In the context of H. pylori-induced inflammation and gastric carcinogenesis, let-7b, miR-103, miR-370, and miR-371-5p are downregulated, while miR-21, miR-25, and MIR584 are upregulated [PMC5081003]. MIR584 has been shown to regulate ovarian cancer progression by targeting lipin-1 [PMC8122924]. Low levels of MIR584 are associated with increased metastasis spreading and poor prognosis in ovarian cancer [PMC8122924]. Depletion of MIR584 expression in ovarian cancer cells leads to increased lipin-1 expression and tumorigenesis [PMC8122924].
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