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Homo sapiens (human) snoRNA (ENSG00000206647.1) secondary structure diagram

Homo sapiens (human) snoRNA (ENSG00000206647.1) URS0000666D1E_9606

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SNORA2: SNORA2 is a small nucleolar RNA (snoRNA) that has been identified as part of a snoRNA signature for the diagnosis and prognosis prediction of renal clear cell carcinoma (ccRCC) [PMC10050728]. The expression of SNORA2, along with SNORD12B, SNORA59B, SNORA70B, SNORD93, and SNORD116-2, has been found to correlate with poor survival in ccRCC patients [PMC8658237]. In cattle, the gene bta-mir-1291, which contains a seed single nucleotide polymorphism (SNP), is located within the intron 9 of the protein-coding host gene KANSL2 and the non-coding snoRNA gene SNORA2 [PMC4379384]. Abnormal expression of snoRNAs including SNORA70B, SNORD93, SNORD12B, SNORA59B, and SNORA2 has been observed in ccRCC [PMC7812721]. The methylation patterns of snRNAs such as SNORA2 have been found to be different in offspring across multiple generations [PMC6890750]. Comparative analysis has shown that human SNORA34 shares more similarity with Xenopus copies of SnoRA2 than with other human copies [PMC6984369]. The correlation between snoRNAs and their host genes has been investigated and high correlation was observed for genes such as snora2 [PMC7011154]. Additionally, six snoRNAs including snora 2 have been identified as independent risk factors for survival in ccRCC patients [PMC7011154]. In ccRCC patients expression levels of snora 70b were positively correlated with their copy number variations (CNVs) [PMC7011154]. SnoRA59b is hosted by a protein-coding gene while snord12b is hosted by a non-coding gene [PMC7011154]. In lung adenocarcinoma patients, SNORA2 was found to be down-regulated [PMC7579711].

Genome locations

Gene Ontology annotations

Sequence

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UAGGCCCUGAAUCAAGACUAGUGUUUUGCUGUAGCUGUUGGUUUCAAACAGGAUCCGAGAGUGAUGUCUUCCUUGUGGUCUGUUCACUGCUCAGUAUCCCAGUGUCAGUGGCCAAUUCAGUUGGAAGCAACAUGG

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This sequence is found in 2 other species

2D structure Publications