hsa-mir-604: Hsa-mir-604 is a primate-specific miRNA that has been found to be expressed in primates, including Homo sapiens [PMC9708597]. It has been shown to target Grin1 in Homo sapiens, as confirmed by a dual-luciferase reporter assay [PMC9708597]. Evolutionary analysis has revealed that novel-m009C may be homologous to hsa-mir-604 [PMC9708597]. The Luc/R-Luc ratio was significantly decreased when hsa-mir-604 was co-transfected with the Grin1 3’UTR, indicating its targeting ability [PMC9708597]. Hsa-mir-604 has been found to be upregulated in the prefrontal cortices of subjects with alcohol use disorders postmortem, suggesting its potential role in alcohol addiction [PMC9708597]. The role of hsa-mir-604 in drug addiction and human diseases is still not well understood and requires further research [PMC9708597]. Phylogenetic analysis has shown that hsa-mir-604 and novel-m009C are closely related evolutionarily [PMC9708597]. In addition, hsa-mir-604 has been identified as one of the hub miRNAs within a miRNA network associated with good prognosis, indicating its potential significance in disease prognosis [PMC8004706]. Hsa-mir-604 is also among the differentially expressed miRNAs associated with high-risk groups in certain diseases [PMC9695425]. Furthermore, hsa-mir-604 has been found to be overexpressed in paracoccidioidomycosis patients and may play a role in oxidative stress regulation and disease prognosis related to TLR4 and CXCL1 genes in acute myocardial infarction patients [PMC8863347].

MIR604: MIR604 is a type of maize event that has been analyzed using bioinformatic methods specified in EFSA GMO Panel (2011a) [PMC7009178]. These analyses have confirmed that MIR604 does not disrupt any known endogenous genes [PMC7009178]. Additionally, when animals were fed balanced diets containing maize Bt11 × MIR604 × 1507 × 5307 × GA21, their measured performance endpoints were similar to those of the control group [PMC7009178]. This suggests that the inclusion of MIR604 in the diet does not have a significant impact on animal performance [PMC7009178].