SNORD88C: SNORD88C, also known as HBII-180C, is a box C/D small nucleolar RNA (snoRNA) that is processed into shorter fragments called small nucleolar RNA-derived RNAs (sdRNAs) [PMC4851398]. These sdRNAs have been shown to have complementarity to fibroblast growth factor receptor-3 (FGFR3) pre-mRNA [PMC4427830]. SNORD88C can influence the alternative splicing of FGFR3 pre-mRNA, leading to changes in the splicing pattern of FGFR3 [PMC7038934]. It has been demonstrated that SNORD88C sdRNAs can suppress the expression of target genes in a sequence-dependent manner through base pairing with pre-mRNA regulatory elements [PMC4427830]. The snoMEN vectors, which are derived from modified versions of snoRNAs like SNORD88C, have been developed as a novel technology for gene expression modulation and can be used for the generation of stable cell lines with targeted protein replacement [PMC4696412]. SNORD88C has also been shown to have base complementarity to intronic regions of FGFR3 and other pre-mRNAs, suggesting its involvement in splicing regulation [PMC8508363]. Additionally, SNORD88C sdRNAs may be involved in regulating mRNA splicing for FGFR3 and other genes through their interaction with target regions [PMC8389557]. The specific involvement and function of sdRNAs derived from SNORD88C are still being investigated [PMC8508363].