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SNORD49B: SNORD49B is a C/D box snoRNA sequence that is part of the lncRNA LNC-SNO49AB, which also contains the snoRNA sequence SNORD49A [PMC9622897]. SNORD49B is located in the middle of LNC-SNO49AB, with SNORD49A at the 3' end [PMC9622897]. Deletion of conserved motifs in SNORD49B did not affect the generation of LNC-SNO49AB [PMC9622897]. When both SNORD49A and SNORD49B domains were deleted from LNC-SNO49AB, it could no longer interact with FBL [PMC9622897]. Both SNORD49A and SNORD49B are located in the second intron of the noncoding gene SNHG29 on chromosome 17 [PMC9622897]. The DNA sequence of LNC-SNO49AB is conserved among primates and also in mice [PMC9622897]. The expression of both SNORD49A and SNORD4B has been shown to be abnormal in leukemia, leading to investigation into the potential role of LNC-SNO4B9AB in leukemia [PMC9622897]. RNA immunoprecipitation assays demonstrated that FBL could bind to LNC-SNO4B9AB, similar to its binding to SNOR4D9A and SNOTD4D9B, while lncRNA transcribed by its host gene did not show FBL binding enrichment [PMC9622897].
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