SNORD53: SNORD53 is a small nucleolar RNA (snoRNA) that is expressed in various tissues, including lymphoid tissues, testes, neurons, and cancer cells [PMC7568261] [PMC8178906] [PMC8522698] [PMC8629011] [PMC5747948]. It belongs to the SNORD53/92 family and is encoded in the same host gene as SNORD92 [PMC8178906]. SNORD53 shows differential expression across tissues, with varying levels of expression in different organs such as muscle, liver, testis, brain, prostate, breast, and ovary [PMC8178906]. It has been found to interact with 28S rRNA and correlate with specific hypomethylated positions in the rRNA sequence [PMC8522698]. In cancer cells with high leukemia stem cell content (AML1-ETO+ samples), SNORD53 is strongly expressed along with other snoRNAs such as SNORD14D, SNORD14E, SNORD20, SNORD32A, SNORD34, SNORD35A, SNORD43 and SNORA74A [PMC8629011]. In addition to its role in RNA modification and cancer cells' gene expression regulation. It has also been found to be upregulated in adrenal and pancreatic tissues of a specific mouse strain (KK/HlJ) along with other genes involved in metabolic regulation and RNA processing such as VNN1 (vanin1), GPT2 (glutamic pyruvate transaminase 2), RPL30 (ribosomal protein RPL30), SCARNA22 (small Cajal body-specific RNA 22) among others. Furthermore it has been found that FBL association with snoRNAs guides such as FBL-SNORA56-SNORA53 targeting modification of 18S-Gm995 was not affected upon TFIP11 depletion [PMC7953684] [PMC8599867].