MIR589: MIR589 is a miRNA gene located in the chromosomal region 7p22, which is prone to gaps and breaks in various cancers [PMC3634031]. In a study comparing different populations, it was found that MIR589 was the only differentially methylated and expressed miRNA in individuals of European ancestry [PMC8453167]. Several other miRNAs, including MIR589, have been identified as overexpressed in breast cancer and have potential applications in diagnosis, prognosis, and therapeutic studies [PMC4508501]. In an experiment investigating the effect of TGFβ1 on MIR589 expression, it was observed that TGFβ1 treatment decreased the expression of MIR589 [PMC3479401]. The decreased expression of MIR589 was also observed in human peritoneal mesothelial cells (HPMCs) isolated from peritoneal dialysis patients and HMrSV5 cells treated with TGFβ1 [PMC3479401]. Additionally, a study on IFN-γ stimulation identified MIR589 as one of the top 10 upregulated miRNAs [PMC8010072]. Overall, these findings highlight the potential role of MIR589 in cancer development and progression.