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SNORD108: SNORD108 is a C/D box small nucleolar RNA (snoRNA) gene located in the Prader-Willi syndrome (PWS) region on chromosome 15q11-13. It is one of the snoRNA genes present in this region, which includes SNORD64, SNORD107, SNORD109A, and SNORD109B [PMC6923197]. These snoRNAs are part of the PWS locus and are involved in the regulation of gene expression [PMC3077502]. SNORD108 is ubiquitously expressed, unlike SNORD109B and SNORD115 which are restricted to expression in neurons [PMC5522075]. It has been found to be co-expressed with other genes such as AC124312.1 and PWAR6 [PMC9582150]. The PWS locus in mice has a highly conserved synteny with the human PWS critical region on chromosome 15q11-13, but lacks orthologues for SNORD108, SNORD109A, and SNORD109B [PMC7038934]. The expression patterns of snoRNAs such as SNORD64, SNORD107, and SNORD108 are highly similar across different human tissues [PMC4171697]. These snoRNAs play a role in PWS as their absence contributes to the deleterious effects observed in patients with this syndrome [PMC7140444].
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