SNORD52: SNORD52 is a C/D box snoRNA that has been implicated in hepatocellular carcinoma (HCC) progression [PMC7415794]. In a study, the effects of SNORD52 knockdown on HCC cell lines HCCLM9 and HCCLM3 were investigated [PMC7415794]. The results showed that the proteasome inhibitor MG-132 could reverse the changes in CDK1 protein levels caused by SNORD52 knockdown, while cycloheximide (CHX) did not have this effect [PMC7415794]. Flow cytometric analysis revealed that SNORD52 knockdown led to a decrease in the proportion of cells in the G0/G1 and S phases, but an increase in the proportion of cells in the G2/M phase [PMC7415794]. Interestingly, SNORD52 was found to be bound by nucleophosmin 1 (NPM1), a phosphoprotein residing in nucleoli. This binding was reported for other C/D box snoRNAs as well, including SNORD42A, SNORD15, SNORD47, SNORD58, and SNORD104 [PMC8629011]. To further understand the role of SNORD52 in HCC progression, gain-of-function and loss-of-function experiments were conducted to investigate its effects on malignant features of HCC cell lines [PMC7415794].