SNORA3: SNORA3 is a small nucleolar RNA (snoRNA) that is overexpressed in tumor-initiating cells and lung tumors [PMC6563001]. Its higher expression in human lung tumors is associated with a lower overall survival rate in lung cancer patients [PMC6563001]. SNORA3 is one of the snoRNAs that are deregulated in cancer, with high expression observed in metastatic breast cancer patients and cell lines [PMC8445368]. It has been found to be overexpressed in tumor-initiating cells and associated with poor prognosis in non-small cell lung cancer (NSCLC) patients [PMC7140444]. SNORA3, along with SNORA42, has been identified as one of the snoRNAs that are highly expressed in NSCLC tumor-initiating cells compared to differentiated lung cancer cells [PMC4029979]. It has also been shown to be overexpressed in lung cancer stem cells and inversely associated with survival in NSCLC patients [PMC6629867]. SNORA3 has been functionally characterized to determine its role in regulating stemness of lung tumor-initiating cells [PMC4029979]. Additionally, SNORA3 has been found to have a precursor confirmed as a small nucleolar RNA-microRNA (sno-miRNA) with miRNA-like function [PMC5814818]. References: - PMC6563001: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563001/ - PMC8445368: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8445368/ - PMC7140444: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140444/ - PMC4029979: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029979/ - PMC6629867: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629867/ - PMC5814818: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814818/