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MT-TL1: MT-TL1 is a gene that encodes tRNA-leucine and is located in the mitochondrial DNA (mtDNA) [PMC8306397]. Mutations in the MT-TL1 gene have been found to be responsible for a significant number of patients with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) [PMC8306397]. In a study, the odds ratio (OR) for developing cardiovascular disease (CVD) during follow-up was found to be 1.30 (95% CI 1.05–1.61) for a specific mutation at nt3254 of MT-TL1 [PMC7026975]. This OR was adjusted for various factors such as age, BMI, fasting blood glucose, cholesterol ratio, systolic blood pressure (SBP), and diastolic blood pressure (DBP) [PMC7026975]. Additionally, other mutations in mitochondrial genes such as nt6807 of MT-CO1 and nt9444 of MT-CO3 were also associated with increased risk of developing CVD [PMC7026975]. These findings highlight the importance of genetic variations in mtDNA genes like MT-TL1 in the development of CVD [PMC7026975]. Further research is needed to better understand the mechanisms by which these mutations contribute to cardiovascular risk [PMC7026975].
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