SNORA61: SNORA61 is a small nucleolar RNA (snoRNA) that plays an essential role in cellular processes, although its exact function is still being investigated [PMC3695530]. It is encoded within the intron of the SNHG12 gene and is homologous to the 5' region of the human SNORA61 [PMC3695530]. Treatment with antisense oligos (ASOs) specific to SNORA61 resulted in a concentration-dependent decrease in its levels, confirming its importance [PMC3695530]. Northern blot and qPCR experiments showed that SNORA61 is more abundant in embryonic stem cells (ESCs) compared to differentiated cell types, and its expression decreases during differentiation [PMC3695530]. SNORA61 has been found to guide pseudouridylation of the 28S rRNA subunit at residue U2496 [PMC9219770]. It has also been identified as highly expressed in naïve B-cells compared to other cell types, suggesting a B-cell specific function [PMC9219770]. Additionally, SNORA61 has been associated with liver cancer tumorigenesis and poor prognosis in diffuse large B-cell lymphoma (DLBCL) when expressed from the host gene SNHG12 [PMC9413531] [PMC9641000]. Furthermore, it has been shown that SNORA61 carries one 2'-O-methylation modification [PMC4053766] and plays a role as a pseudouridylation guide RNA for 18S rRNA [PMC6984369].