MT-TR: MT-TR is a gene that plays a role in various biological processes and is associated with different conditions. It contains a homopolymeric tract of 8 consecutive adenosine residues [PMC3258376]. The anticodon of MT-TR can vary among different species, with some having TCG and others having ACG [PMC8727539]. Certain regions of MT-TR, such as the origin of light strand replication and the polymorphic region, were ignored in a study [PMC2214808]. PCR was used to amplify the MT-TR gene from total genomic DNA using specific primers [PMC3258376]. A hotspot for mutations was identified in the MT-TR gene, and one particular point mutation was found to be common in certain tumor samples but not in normal tissues [PMC3258376]. The polymorphic nature of MT-TR is well-known among common inbred strains [PMC5897405]. A single nucleotide insertion in the MT-TR gene was found to be responsible for a phenotypic effect [PMC4366423]. Additionally, MT-TR is one of several genes analyzed for genetic causes of channelopathies and cardiomyopathies [PMC7290503]. In one patient, a deletion spanning several genes including MT-TR was observed through direct sequencing of mtDNA [PMC3592399]. References: [PMC4366423] [PMC3258376] [PMC8727539] [PMC2214808] [PMC5897405] [PM7290503] [PM3592399]