hsa-mir-4686: Moreover, a study found that 60 miRNAs were downregulated in severe patients, with the most downregulated miRNAs including hsa-miR-7848-3p, hsa-miR-7110-3p, hsa-miR-1197, hsa-mir-4686, hsa-miR-374b-3p, hsa-miR-4473, hsa-miR-758-3p, hsa-miR-5004-3p, hsa-miR-146a-3p, hsa-miR-329-5p, hsa-miR-744-3p, hsa-miR-1285-5p, and hsa-miR-6516-3p [PMC8890551]. In another study, it was observed that hsa-miR-4669 and hsa-mir-4686 levels were significantly downregulated in the effective group, while hsa-miR-3196 concentration was upregulated [PMC9451037]. Additionally, predicted miRNAs, including hsa-mir-4686, hsa-miR-3686, hsa-miR-4652-3p, and hsa-miR-215-3p, were identified [PMC5760646]. Furthermore, eight miRNAs, including hsa-mir-4686, hsa-miR-490-5p, hsa-miR-5589-3p, hsa-miR-490-3p, and hsa-miR-7704, were downregulated more than twofold, while 61 miRNAs, including hsa-miR-1269a, hsa-miR-137, hsa-miR-522-3p, hsa-miR-518b, and hsa-miR-512-3p, were upregulated more than twofold [PMC10083302]. Finally, two miRNAs, hsa-mir-4686 and hsa-mir-3691, were found to have chimpanzee-specific substitutions and presented significant p-values [PMC4966751].