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Homo sapiens (human) hsa-miR-4741 URS0000547F6A_9606

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hsa-mir-4741: Hsa-mir-4741 is a microRNA that has been found to be differentially expressed in various diseases, including Alzheimer's disease (AD), colorectal cancer (CRC), gastric cancer (GC), and intervertebral disc degeneration (IDD) [PMC8698767] [PMC4121995] [PMC7759842] [PMC9755594] [PMC9522702]. It has been identified as one of the miRNAs that can differentiate AD and control participants, along with hsa-miR-4668-5p, hsa-miR-3613-3p, hsa-miR-5001-5p, and miR-4674 [PMC8698767]. In colorectal cancer cells, hsa-mir-4741 has been found to have elevated expression levels compared to control cells [PMC4121995]. In gastric cancer and colorectal cancer, hsa-mir-4741 has been associated with the disease along with other miRNAs [PMC9522702]. Additionally, hsa-mir-4741 has been predicted to be sponged by a circular RNA called hsa_circ_0005556 in a ceRNA network analysis [PMC7521983]. It is also part of a ceRNA network in intervertebral disc degeneration involving BIRC5, OIP5, and AR genes that still needs experimental verification for reliability and validity [PMC9524080]. Furthermore, in a study on Alzheimer's disease biomarkers, hsa-mir-4741 was one of the upregulated miRNAs with an AUC score of 0.875 for differentiating AD patients from controls [PMC9039132]. Overall, these findings suggest that hsa-mir-4741 may play a role in various diseases as an important regulatory molecule.

Genome locations

Gene Ontology annotations

Localisation

Sequence

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CGGGCUGUCCGGAGGGGUCGGCU

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