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SNORA68: SNORA68 is a small nucleolar RNA (snoRNA) that has been studied in various diseases, including cancer and schizophrenia [PMC6439315]. Several studies have developed risk assessment models based on snoRNA expression, including SNORA68, to predict overall survival in cancer patients [46–48]. Gao et al. developed a risk formula that identified SNORA68 in non-small cell lung cancer patients and validated it in a testing set [46]. Similarly, Zhao et al. established a risk assessment model using SNORA68 and other snoRNAs in clear cell renal cell carcinoma [35]. However, many risk assessment models based on snoRNA expression have not been validated in clinical cases [PMC9005336]. In non-small cell lung cancer tissues, SNORA68 has been found to be upregulated compared to adjacent normal tissues [PMC8017274]. In ovarian cancer patients, high expression of both SNORA68 and another snoRNA called SNORD74 is associated with poor prognosis [PMC7862201]. These two snoRNAs can predict poor overall survival specifically in serous adenocarcinoma of the ovaries [PMC7862201]. Additionally, the combination of SNORA68 and SNORD74 can predict clinicopathological features associated with poor prognosis in ovarian cancer patients [PMC7862201]. Overall, the studies suggest that SNORA68 is involved in disease pathogenesis and can be used as a prognostic marker for various cancers.
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