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MIR181B1: MIR181B1 is a member of the miR181ab1 cluster, which is a key regulator of KRAS-driven carcinogenesis in lung cancer (LC) and pancreatic ductal adenocarcinoma (PDAC) [PMC8430834]. It has been found that certain miRNAs, including MIR181B1, are induced or suppressed upon differentiation [PMC4168020]. MIR181B1 has been implicated in the onset of manic symptoms in bipolar disorder (BD) and has been found to be downregulated in schizophrenia patients with antipsychotic medication [PMC6504680]. On the other hand, MIR181B1 is upregulated in the manic state and shows higher expression in treatment-resistant schizophrenia patients [PMC6504680]. In addition, MIR181B1 has been identified as a gene marker of BD manic episodes [PMC9554663]. Studies have shown that MIR181B1 is necessary for proficient induction of tumorigenesis by mutant KRAS and regulates cell cycle progression [PMC7108928]. It has also been found that combined overexpression of miR181a1 and MIR181B1 enhances tumor growth and cell proliferation rate compared to single overexpression or knockout models [PMC7108928]. Furthermore, miR181a1 and MIR181B1 have non-redundant functions but may be needed together to generate a threshold level of miR181 RNA required for the full oncogenic phenotype [PMC7108928].
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