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hsa-mir-335: Hsa-mir-335-5p is a microRNA that has been found to play a role in cancer progression, specifically in colorectal cancer (CRC) and other types of cancer [PMC7960496]. Studies have shown that high levels of hsa-mir-335-5p are associated with poor prognosis and metastasis in gastric cancer patients [32]. Similarly, high expression of hsa-mir-335-5p has been observed in uterine sarcoma patients with tumor metastasis and relapse, suggesting its potential as a prognostic marker [33]. In the context of CRC, upregulation of miR-335-5p has been found to promote the invasive ability of CRC cells [PMC7960496]. Additionally, single nucleotide polymorphisms (SNPs) in hsa-mir-335 have been identified to result in loss and alteration in cleavage site [PMC3851333]. In a study measuring the expression levels of various microRNAs, including hsa-mir-335, it was found that RNU48 and cel-miR-39 were used as internal and external controls, respectively [PMC8870702].
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