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hsa-mir-373: Hsa-mir-373 is a microRNA that is closely associated with breast cancer invasion and metastasis [PMC3608627]. In a study, secondary targets of hsa-mir-373 were investigated, and it was found that hsa-mir-373 regulates various miRNAs that play a role in breast cancer [PMC10131518]. These miRNAs include hsa-miR-24, hsa-miR-21, hsa-miR-200s, and hsa-mir-373 itself [PMC10131518]. Additionally, SNPs located in various miRNAs were selected for analysis, including miRNAs that regulate breast cancer-associated genes such as RAS, PTEN, ATM, BRCA1/2 (hsa-mir-149, hsa-mir-196a-2, hsa-mir-30c-1, hsa-mir146a and has let7f2), miRNAs regulating breast cancer-associated receptors ER (estrogen receptor), PR (progesterone receptor), and HER2 (human epidermal growth factor receptor 2) (hsa mir27a , has mir125b1 , has mir1051 , has mir1052) [PMC3608627]. These findings suggest that hsa-mir-373 plays a crucial role in breast cancer progression by regulating other miRNAs involved in various aspects of the disease such as gene regulation and receptor expression [PMC10131518] [PMC3608627].
mRNA interactions
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