gga-mir-454: Gga-mir-454 is a microRNA that has been found to inhibit the replication of infectious bursal disease virus (IBDV) by targeting the viral genomic segment B and enhancing the expression of interferon-beta (IFN-β) by targeting cellular SOCS6 [PMC7063076]. It has also been shown to inhibit myoblast differentiation and the expression of MyHC and MyoG genes [PMC7324647]. Gga-mir-454 has been found to be down-regulated during IBDV infection, and its overexpression enhances the expression of IFN-β, IRF3, and p65, thereby inhibiting IBDV replication [PMC9607458]. Gga-mir-454 can also target the viral genome B and SOCS6 to inhibit viral replication [PMC6862082]. In addition, gga-mir-454 has been found to be down-regulated in fat line chickens [PMC4326283]. Other microRNAs that target SOCS genes, such as gga-miR-155, gga-miR-130b, and gga-miR-21, have also been shown to inhibit IBDV replication [PMC9721073]. Overall, gga-mir-454 plays a significant role in inhibiting IBDV replication by targeting both viral genomic segments and cellular factors involved in immune response regulation. However, further research is needed to fully understand its mechanisms of action during IBDV infection.