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hsa-mir-519e: Hsa-mir-519e is a miRNA that belongs to the miR-515 family and is coded in a cluster on 19q13.42 [PMC7648123]. It has been found to be upregulated in primary ACC [PMC5929417] and downregulated in preeclamptic placentas [PMC8666996]. Hsa-mir-519e is overmutated in Pan-Cancer, as well as in ovarian (OV) and breast (BRCA) cancers [PMC7648123]. It has been identified as a target gene of hsa_circRNA_0079201, along with other miRNAs such as hsa-miR-140-3P and hsa-miR-1225-3P [PMC7595675]. Hsa-mir-519e is expressed at low to medium levels in THYM, BLCA, and TGCT cancers [PMC7648123]. In the context of PTCL/NOS, ALCL/ALK−, and AITL cancers, hsa-mir-519e has been found to be differentially expressed along with other miRNAs such as hsa-miR-515-3p and hsa-miR-652 [PMC4335255]. In addition, it has been shown that the upregulation of hsa-mir-519e is associated with downregulation of its potential targets ATR and PYHIN1 [PMC3886917]. RFC4, ZWINT, TYMS were identified as hub genes associated with GBM tumorigenicity along with transcription factors TATA-binding protein (TATA), E2F transcription factor 4 (E2F4DP1), and hepatocyte nuclear factor 4 (HFH4) [PMC6180049].
mRNA interactions
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Genome locations
Gene Ontology annotations
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Sequence
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