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hsa-mir-769: Hsa-mir-769 is a microRNA that is not conserved in mice and does not have a potential cleavage role [PMC3333847]. In breast adenocarcinoma cell line MCF-7, hsa-mir-769 has been found to inhibit the expression of N-myc downstream-regulated gene 1 and enhance apoptosis [PMC6208346]. Hsa-mir-769, along with hsa-miR-200c, hsa-miR-1185, and hsa-miR-146b, has been associated with breast cancer prognosis [PMC6208346]. Hsa-mir-769 has also been found to be differentially expressed in male breast cancers and between African-American and non-Hispanic white women with triple negative breast cancer [PMC6208346]. In African-American women with triple negative breast cancer, hsa-mir-769 was upregulated compared to non-Hispanic white women [PMC6208346]. The expression levels of hsa-mir-769 in the early stage group of breast cancer patients were 4.88 ± 0.70, while in the advanced stage group it was 4.75 ± 0.77 [PMC6208346].
mRNA interactions
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Genome locations
Gene Ontology annotations
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Localisation
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