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SNORD62A: SNORD62A is a small nucleolar RNA (snoRNA) that has been studied in various contexts. In a study using confirmatory samples, the presence and selective sensitivity to NSUN2 KD were confirmed for four sites in ncRNAs, including SNORD62A [PMC7158060]. Another study explored six candidate m5C sites using two prostate cell lines, and evidence of non-conversion was observed in SNORD62A [PMC7158060]. The sites in RPPH1, SCARNA2, NSNU5P2, and SNORD62A were further validated in independent biological samples [PMC7158060]. In the context of invasive breast cancer, SNORD62A was among the most highly upregulated snoRNAs in the MDA-MB-231 cell line [PMC8445368]. The binding of 15.5k protein to SNORD62A snoRNA was explored with and without N6 methylation of A1n using isothermal titration calorimetry [PMC5579392]. Overall, these studies highlight the presence and sensitivity of SNORD62A to various factors such as NSUN2 KD and methylation.
SNORD62B: SNORD62B is a small nucleolar RNA (snoRNA) that has been studied in various contexts [PMC7158060]. In a study using confirmatory samples, the presence and selective sensitivity to NSUN2 KD (knockdown) were confirmed for four sites in ncRNAs, including SNORD62B [PMC7158060]. The sites in SNORD62B, along with other ncRNAs and mRNAs, were further validated in independent biological samples [PMC7158060]. Non-conversion was observed in SNORD62B, indicating the presence of modified nucleotides [PMC7158060]. Additionally, SNORD62B was found to be differentially expressed and highly upregulated in invasive breast cancer cell lines [PMC8445368]. The binding of 15.5k protein to SNORD62B snoRNA was explored using isothermal titration calorimetry [PMC5579392].
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