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dre-miR-29b: dre-mir-29b is a microRNA that is induced by cold shock and has been found to target the per2 gene in zebrafish larvae [PMC5111229]. The expression of dre-mir-29b increases initially after cold shock but then drops at 24 hours post-infection [PMC5111229]. There is a correlation between the expression of dre-mir-29b and per2, with dre-mir-29b acting as an inhibitor of per2 expression [PMC5111229]. The 3' untranslated region (UTR) of per2, which contains the target site for dre-mir-29b, has been amplified from a cDNA library [PMC5111229]. The changes in the expression of dre-mir-29b and other cold-affected miRNAs have been validated using qPCR analysis and compared to small RNA-seq results [PMC5111229]. It has been shown that dre-mir-29b can enhance the cold tolerance of zebrafish larvae by fine-tuning the expression of per2 [PMC5111229]. The expression levels of both dre-mir-29b and per2 are elevated at 4 hours post-infection [PMC5111229]. By using a morpholino oligonucleotide (MO) to inhibit dre-mir-29b, it has been demonstrated that it can control the expression of per2 induced by cold shock [PMC5111229]. Dre-miR-101a and dre-miR-101a are also involved in regulating EMT-related genes in zebrafish larvae [PMC7756072]. Dre-miR-29a mimic or Dre-miR-29b mimic have been microinjected into zebrafish embryos to study their effects on gene regulation [PMC5304403].
mRNA interactions
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