SNORA6: SNORA6 is a box H/ACA-type snoRNA gene that is encoded from the host gene RPSA or Laminin receptor (LAMR) in vertebrates [PMC6466398]. It is believed that SNORA6 arose from the cis-duplication of SNORA62, as they share the same host gene [PMC4515611]. SNORA6 has been found to be up-regulated in metastatic lesions and in normal prostate, localized prostate cancer (PCa), and metastatic PCa samples [PMC5423162]. It has also been shown to be significantly altered in H19-expressing LFS osteoblasts [PMC7844330]. In chronic lymphocytic leukemia (CLL), SNORA6 is down-regulated, along with other snoRNAs such as SNORA31, SNORA62, and SNORA71C [PMC8975097][PMC9219770][PMC8629011]. The dysregulation of snoRNAs, including SNORD116-18, SNORA70F, and SNORD1A, has been associated with shorter progression-free survival (PFS) in CLL patients [PMC8975097]. In addition to its role as a snoRNA gene, it has been suggested that the host gene of SNORA6, RPSA or Laminin receptor (LAMR), may play a role in tumor-related signal transduction [PMC3766210]. The expression of SNORD116-18 and other snoRNAs has also been associated with high-grade ovarian cancer [PMC8759569]. These findings highlight the potential importance of snoRNAs like SNORA6 in cancer biology.