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MIRLET7F1: MIRLET7F1 is a microRNA gene that is included in a custom gene panel designed for mutation profiling of pediatric cancers [PMC7341754]. The panel includes coding exons of 366 cancer-associated genes, untranslated regions and introns of 16 genes for detecting structural variations, and specific regions for detecting TERT rearrangement and promoter/enhancer mutation [PMC7341754]. In addition, the panel includes the promoter and enhancer regions of FGFR3 and MYC, as well as 11 microRNA genes including MIRLET7F1 [PMC7341754]. In a study, MIRLET7F1 was identified as one of the candidate target genes in pediatric cancers [PMC5791735]. MIRLET7F1 interacts with HNRNPM along with other miRNAs, protein coding genes, rRNAs, lncRNAs, and pseudogenes [PMC9730017]. The SNP rs10512230 is flanked by the PTPDC1 gene along with MIRLET7A1 (Let-7a-1), MIRLET7F1 (Let-7f-1), and MIRLET7D (Let-7d) genes [PMC6202974]. These microRNA genes including MIRLET7A1, MIRLET7F1, and MIRLET7D are involved in cancer and DNA damage response pathways [PMC6202974]. The custom gene panel used targeted capture technology to analyze various genomic regions including microRNA genes like MIRLET7F1 for copy number analysis in pediatric cancers [PMC7815088].
Genome locations
Gene Ontology annotations
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