SNORD59A: SNORD59A is a small nucleolar RNA (snoRNA) that has been identified as a tumor immune infiltration-associated snoRNA and a positive prognostic factor in bladder cancer [PMC8844792] [PMC8844792]. It has also been found to be upregulated in clear cell renal cell carcinoma and can be used as a diagnostic marker [PMC8844792]. SNORD59A is one of the snoRNAs that were screened out as tumor immune infiltration-associated snoRNAs and included in the random survival forest (RSF) model construction [PMC8649667]. It is also one of the snoRNAs whose expression levels were significantly reduced in tumors and increased in immune cells, making it a potential prognostic factor for colon cancer patients [PMC10050728]. SNORD59A is located on chromosome 12, along with other snoRNAs such as SNORA2B and SNORD59B, which are upregulated in patients with an extra chromosome 12 [PMC9219770] [PMC3766210]. The expression levels of SNORD59A are inversely proportional to the TIIsno score, indicating its potential role in tumor immune infiltration [PMC8844792]. Additionally, SNORD59A is located upstream of SNORD59B within an intron of the protein-coding transcript encoding ATP synthase subunit d (ATP5PD) [PMC9175010]. Overall, SNORD59A has been identified as an important snoRNA with potential diagnostic and prognostic value in various cancers.