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Homo sapiens (human) lncRNA imatinib upregulated (LNCRNA-IUR) URS000043ABCC_9606

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LNCRNA-IUR: In a study, a conserved, imatinib-upregulated LNCRNA-IUR was identified and shown to function as a suppressor to inhibit Abl-transformed cell survival in vitro and tumor growth in vivo [PMC6454664]. LNCRNA-IUR deficiency was found to promote Abl-transformed leukemic cell growth in vivo [PMC6454664]. The study also found that NS2 cells were more likely to infiltrate the spleen of LNCRNA-IUR knockdown (KD) mice compared to wild-type (WT) mice after induction of leukemia [PMC6454664]. The functional relevance of LNCRNA-IUR in Abl-mediated tumorigenesis was further investigated using LNCRNA-IUR KD transgenic mice and WT littermates, which were developed for leukemia [PMC6454664]. The upregulation of LNCRNA-IUR by imatinib was confirmed in leukemic cells using quantitative real-time PCR [PMC6454664]. It was suggested that there may be no regulatory relationship between LNCRNA-IUR and SESN3 in Abl transformants [PMC6454664]. Knockdown of LNCRNA-IUR provided an ideal tumor microenvironment for Abl-mediated leukemia development, while overexpression of LNCRNA-IUR suppressed cell survival and tumorigenesis [PMC6454664]. The expression of several transcripts of the LNCRNA-IUR family was found to be upregulated by imatinib treatment in Bcr-Abl-positive cell lines [PMC6454664]. Additionally, the level of LNCRNA-IUR expression was significantly lower in Bcr-Abl-positive ALL patients compared to normal subjects [PMC6454664].

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Gene Ontology annotations

Sequence

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CACAAACAACUUUGAGUCCCGGGAGGGCGGAGGUGGAGAGAGAUUCUCCGCUUGGAUAAGGGCGGCUGGAUAGCCGAGUACUCUCUUUUGGGGCUGUUGGCCGUCUCCGGAGUCUCGGGAGCGCCUUGAUGUCCCUUCCCAGGGCUCGGGUUCCUUUGAGAGAAUCAAGAGGAAGGUGUUUUUCACUAGGACUCGCGGUGGGCCCCACCUGCCUACCGUGGCCGGCCGGGAGCUAUUACAGCAGGGUCUGCCCGUCCGACGACGGCGGCUCCAAUCUGGGGUCCCGCCGGCGCCGACCCCUCAGCUCUCUCCCGAUACCUGCUGGCCUCUCUCAUCUUUGGUGGCACUCGCCGCCACGGGGACGGUGAGAUCAAAGAGGUAGACCUAGGCCAGGAGGGACUGCCAGGGCUCCUUCCCGCGGGCCAGCCUCUCGUCCUUCCUCCCGGGACGGGGCUCUUUCCCUUUCUCCGGAUGCGGGCCUUUGAGAGUCAGCGACGCCUUAGACUCCUCCCAGAAAAAUGCACCCUCAUCUACCCAAUUCUGCCCUACCCUUUGGAGCUCCUGGACCCUCUAACCGCUCGGUGGGGUCAGAGCCCACCCCCGGAAGGGCCGCUGGUCGGGGACUGGUUCGCCCUCUCCUGGCCUCCUCGGACCAGUGCGCGGGGAGGAUCCCGCUAACGCCGGGCGCCUGCAGACCUUGAGCGGCCUCGCCCUGGUGACCUCCCCGGGAAAGGCUGGGCGGUGCUUCCACAAUGAGGGCCACCUGUUAAUUUGCACGAGAAAGUGCUGCCGAGGGCCCACACGUGCGAAUCCACCUGUGGAGUGCGUCCCCUCUCUGGGGCCAAGGCCUAGGGGAGGCCGAAGCGGAGAAGUUGCCUGAAGACUGGGAAGUAAGAGUAGGGGCGUCGGAGGAAUCGAAGUUGCAGUGACAUCAGGCUCGGACAGCCGGCGGACUCCUCGCAAGGUGAUCGGAUACUUCCGAGAGCCCCACAGUCCUCCUGGGCCUUUGCCCUCGCGUCUGGGAUGCGCUCGGGCGCCCCCAGUCUGCGAUGCGUUCGUACCUCCAGUAGGGUGACGUUUUCGCCGGGCCCCUCUGCGAACAGUCUCCGCCCUCCUCCACUGUGAGAUAUUUCACAGUUUCACCCGCAGAGGGCAACCUUAUUCCAAGUUCCCGAGCGCCCUAGGCCUCUUUCUCCUCCCUGCCUAACUGGCCUCAAACUUCUUCAUGGGAAAAGAUGGCUUCUCUUUUUUAAUUGAAUGAACUAGAAGAAGUUCAUUGUUAUUCAUCAACUUCAAAGAGACUAUAUGAGGCCCCUUGGCCAGGACUACAGAGCAGUAUUUUUUAAUCAGAAAUUAUAGCCAAAAAGAAGAGACCAGAACACAUGGAUGAAGAAGGAAGGCAUUAAAGAUUAUGUAAUUUGCUGGGUGUGGUGGCUGACGCCUGUAAUCCCAGCACUUUGGGAGGCAGAGGCUGGCGGAUCACUUGAGGUCAGGAGUUCGAGACCAGCCUGGACAACAUGGCAAAAACCUGUCUUUACUAAAAAUACAAAAAUUAGCCAGAUGUGGUGGUGGGCGCCUGUAAUCCCAGCUACUUGGGAGGCUGAGGCAUGAGAAUCGCUUGAACUCGGGAGGCAGAUGUUGCAGUGAGCAGAGAUGGCGCCACUGCACUCCUCCCUGGGCGACAAAGCAAGACUCCGUCUCAACAUCACUGAACCAGUAGGGGGCAGAGCUGGAAGUUGAGCCUAGGUGUGUCUGACUCCACAGCCUACGCCCCGAACCUUGACUUUGUGCUUUCUCACAAUGCCUAUGGCUGCUGCUUUAAAACAGCACUUUCCAUUUGCCUUGUUAAAUGGGAUUGUAUAUGAAUUAUACUUCACUGUUUAUUUCUAGAGAAAUAAAAGAAUCUAAUAAAGGAAUCUGACACGG

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Expression New Publications