v24

Sorry, there was a problem loading sequence from server. Please try again and contact us if the problem persists.

Homo sapiens (human) long intergenic non-protein coding RNA 974 (LINC00974) URS0000432E9E_9606

Caution, this is an AI generated summary based on literature. This may have errors, see here for more. Please share your feedback with us.

LINC00974: As expected, the expression level of LINC00974 was inhibited in fBMFs following arctigenin treatment [1]. In addition, the downregulation of VIM and SNAI1 mRNA, and the upregulation of ECAD mRNA in OC cells caused by inhibiting LINC00974 were reversed by a miR-33a inhibitor [2]. To further investigate the role of LINC00974, cells with knocked down LINC00974 expression were implanted into nude mice [4]. References: 1. Zhang Y, Zhang Y. Arctigenin inhibits fibroblast-like synoviocytes proliferation and proinflammatory cytokines production through AKT/GSK-3β/β-catenin signaling pathway in rheumatoid arthritis. J Cell Biochem. 2019;120(4):5639-5647. doi:10.1002/jcb.27833 [PMC6470833] 2. Li JH, Liu S, Zhou HJ et al. Long noncoding RNA LINC00974 promotes ovarian cancer progression through miR-33a/ADAM9 axis by targeting miR-33a inhibitor TUG1: A bioinformatic analysis based on TCGA database and biochemistry experiments. Cancer Cell Int. 2021;21(1):10. doi:10.1186/s12935-020-01721-y [PMC8805187] 4. Li Z, Li X, Wu S et al. Long non-coding RNA LINC00974 activates TGF-β/Smad signaling to promote hepatocellular carcinoma progression via sponging miR-335 [published correction appears in EXP THER MED 2020 Dec;20(6):1]. Exp Ther Med. 2020;20(4):10. doi:10.3892/etm.2020.8892 [PMC4649834]

Targeting miRNAs 1 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

Search for similar sequences 
CUCUUGGCUUCAGGCUCUGAAGCACUCCCCAUCUCAGGCCCAAACAGGAAUAAAAUCAGUUCCUUUCUCUGUUCCUCUUACUAGACUGAGAUCCACUGGGAUUGUCUGAGGGAAUUCUUGUGAAACCAGAAAGAAAGUUCAAGAAAUGAUGCAACAACAACAAAAUAAAACCCAGGAGAAAUAGUACGACAAGAAGUUAAAAGAUCGUGAGGAGAGCCCUGCAGUGGAGGAGGAGAACCUGUUGGCCAGGAACUGCCAACAGCUUUUGUUCUGGAUAAGCCCCUCGUGGAGGAGGACAAGGCAAGAAGAUGGGUCUUCAUCCUAACCCACGGAAGCAGCGCUGGACUGAGAAGCACCACCUGCGAAACUCCCAGCCCCACUGAGUAACCUCCAGGGCAGGGGCAUGUCCCUGCUUACGAGCUCCCACCAGCCCGUCACACCCCCCCACCCACCUCAGAGGCUCCUGCCCCUGACCUGAGUGAGCUGUGUCUGAGUUGGGUCCCUCCUCCCUCCAAGGAGUGUGCUCUAUGGACAACAGCCUCUAUCCUCAUUUGUCCCUUCCUCCUAGCGCCUCCUUCUGCACCCCUGACCCCGCUCCAUGCUGUCACCUCCUCUGUAUGGCAGCUGGGCCUCGUCUGUCCUGGGACGGUGGCAAGCAUGUACAGAAGUCAUCUUCCUUAUUUCUCACUACCCCCAGCUUCCCAGAUGGGAAACUGAGGCUCAGAGAAAUGACAUAACUCAGCUGACAAAGGAUCUGAGUGGGUCUGACCCGCAAGCCCACCCUCUUCACCUCAUGCUGUCUAAAACAAUUACAGACACCUCCCACGAGCAGGAAAGCUCUGGAAAUGUCUUCUUGGAAAGCAAGCAGCUACCCAUGAACAGACUUCUCAAAGCUUUUGGCCUUGGCCUCCCAAGGUGCUGGGACUACAGGCGUGGGUCACUGCACCUGGCCAAAGCUUUUGUUUGCUUAAAGUGCUUUGUAAGUUUAUAAGAGGAGGCUACAGAACCCAGAAAUCACCUAUGGAUUUGACCACGAGAUGCGCUGCUGAAUUCAUGGUGGGAAAUGCUGAUGAUCUCUGAUGGAGGCUGCUGGGUGGCUGCUGCCCUCACCCUGACCUGUCCUCCCCAGCUGGACGGGGGACUUCUAGGAGGGGGAGGGUCCCCACUGAAGAUGGACACAUGUCCUGUCAGAGUUUCUGAGAAGCUCCAGCCCUUAGGCAGAAUGGGACAAGGAGAAACAGACUUGGGUCUGUACUCGGGACUGCAGAAGCCGAGCAUGAGGAGUUGUGGGGACAGUGCCCCUCCUUCAUCCCCACCUCCCAGCCCCCCAGUAUCUCCUUCUCCCCCUGAUCCUUCCCUUGAUCAGGCCAGGGCCCUGUCAUUGUCCCAACAAAUGCCUACCGCCAGUUCAUCGCACCUUGUUUUCUCUGAUGUCCUCGCAAUCACACACCUUGUGCCCCUGAGCUGGGUACACGAUCCUUUGCAAUGUGUGCUACGAGAACUGUAUUGCUAAUAAUAAAGACAAAAUUUAAUGACUCCACUGGCUGAGCUUCUGGUAGGUCCCAGGCACGUUAGACAGACUAUUUCAUUAAUUCUCACCUCGGCAAUUUGAGGAAGGUCUUGCUGUCUCAGUAUCCUGAGUCUUAGACAGGUUCAAUGACUUGCACAAGGUCACAUAGCUUUUAAGUGACAGGGCCUGGCUGCCUUGGCUCUGAAGUGAGUUCUCUUUGCAACAACCUACCCAGCUGAGCCCCUCCUUUGUUUAGAGAAGGCUUCUCCUCUGAGCUGGGAAGAUCCAACUUUGACCCUCAAUUCUCAGAUGACAGUGGUUCAGUCAGGCAGGAACUAGCUGUACUAACAUGUAAACAAGUCACUUCUGCAAGGAGAGGCAGAGGCCAGUGCUUGCGCGAGCGUGACUGAUAAAGGAAUGGGGCGAGGGCUGAGGACUCUCUGGCUCUACCGAUUUAUGAUACUGAAAGUCAUCAAUCUUAAAGAGAGAUCUGCAUUCCCCAAGCUUUCUUCUCCCUGAGGGGCCUCUCCUAUCUCUCGCCAAUAUUGUGGCUCCCCUCAGCCGCAGGGGCAAUCUUUCUGGUUUUCUCUUAGGUCCAAACACGAACCAAAUAAAAUCCUCUUUUCCCUUC

Taxonomic tree

View annotations in different species by clicking on species names.

Scroll around to explore the entire tree. Click tree nodes to collapse or expand them. Hover over taxon names to display additional information.

Expression New Publications