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hsa-mir-940: Hsa-mir-940, a type of exosomal microRNA, has been extensively studied in relation to prostate cancer (PCa) and gastric cancer (GC) [PMC8129505] [PMC6111604]. Exosomal hsa-mir-940 secreted by PCa cells has been found to induce the transformation of bone marrow mesenchymal stem cells into an osteoblast phenotype in the bone metastasis microenvironment [PMC8129505]. This transformation is mediated through the targeting of ARHGAP1 and FAM134A by the exosomes [PMC8129505]. Ultimately, this process promotes bone metastasis of PCa [PMC8129505]. Additionally, hsa-mir-940 upregulation has been observed in GC tumor tissues and PC salivary samples [PMC6111604]. These findings suggest that hsa-mir-940 may play a role in both PCa and GC, although its specific functions may vary between these two types of cancer. Further research is necessary to fully comprehend the mechanisms by which hsa-mir-940 contributes to tumor progression in these contexts [PMC8129505] [PMC6111604].
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