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Homo sapiens (human) long intergenic non-protein coding RNA 667 (LINC00667) URS00003F999A_9606

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LINC00667: LINC00667 is a long non-coding RNA (lncRNA) that is part of the main functional module in the PCLMN, along with H19 and BCL11B, a transcription factor expressed in all T-cell subsets [PMC8034915]. BCL11B has been shown to enhance NF-kB activation triggered by TCR/CD28 [PMC8034915]. LINC00667 is located in the cytoplasm and has been found to be post-transcriptionally regulated by YY1 [PMC7368754]. In a western blot experiment, it was observed that the deficiency of HNF4A led to a reduction in TNF‐α, IL‐1β, and IL‐6 protein levels. However, this reduction could be reversed by overexpression of LINC00667 [PMC9082386]. To validate the entire mechanism of LINC00667 in colorectal cancer (CRC), rescue assays were conducted [PMC7368754].

Targeting miRNAs 18 total

According to LncBase, this RNA is targeted by the following miRNAs:

Genome locations

Gene Ontology annotations

Sequence

Sequence features are shown above as colored rectangles. Zoom in and click to view details, or Reset

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GAGCGGGGAGCAAGGCCUGCGGGGAGGCGCAGGAUGGACGCGUUGGCUGUCAUGAUGUAGGACCUCCUGACCUAGAACCAUGCCCGGCGCAGGGAGAACAACGAGCUUACGGACCGGGUGCGGGGGCUGCUGUGCGAGAAAGCCUACCUGCUGGCCCGGGAGCGUUCGCCGGCCCACCUGGUGGCUUUCCCUGGACGUUUAACGGCGACUCCGCCCGGCCUCCCGACUUUUUGAUGCAGGCGUUCUCUUACAUGACUUUCUUCGAGGCUAGAUUCUCGAAAGACAUCCUGAAGGUGGCUUUCUUAAUUAGCUGCCUCACCGGCUGGCGGAGCAGUUCGUAGUCGCCUACAUCGAGAGGGAGAGCCCCGUCCUGGCUCAGUACUGGGGCUUCGUGGACGCGCUGUAGCGGGUCUUCGCCGUCGUGGGUAGGAAACAGUCGGGCCGGAUCCCCGGUGUCUGGGGAGCGGCUGCCGGCCGGGCCCGCGCGAGCCGCUUCACUCCUACAAGCCCGGCUCACUAGUUCCAAGCUGCUGGACUUUGACCCUCGCUGGGAAGCUUGAUCGCCGCCUGUUCUCGCCAAUCUCUAUGCCUUUGCACUGCCCAGCAACCCGGUCACUGCCCAGGACCUGUUAAAAGUUGAAUGGACCUCCCAGAAUCACGCCGCUGCCACCGCCGUUUCUAGAGACGGCUUUUGGCCACCUUUGAGAAUCAGGGUCAAACUUGGAAGGGCCUGCAUUUGUCACACUUCCUCGGACACUAAUUUGGAUAGUUCAGGCCCAGAGACGGCUUCCCGGGUUAGUGUGCCUGACAACACUGAAGAAAAAUUGUGACAUUUUCCUUCCCCAGAAUUACUUCGUUUUAUACAUUUCACUUCUCUUCUGAAAUCACAGCAAUGCCAGUUUGCGCCUUUUGGUCUGAGGAACGCAGGCCCUGGCCACUACCAGGAAAAAAUCCUUUGCACAUGGCCUGCUAUCAACAAUCCUCUACAAUGAUUCUCAGCAUCACCUAGGGAGCUUAUGUAAAAUCUCAAAUUCCUGGGCCCUAUCCCCAGAGUUUCUUAUCAAUUUCCUUGAUGGAGAACUAUCAAAGCAGUCAAAGCUAUCAAAAUAAAAAAGAAUUCUGAUUGGGUGCAGUGGCUCACACCUGUCAUUCCAGCACUUUGAGAGGCCAAGGUGGGCAGAUCACAUGAGGCCAGGAGUUCAAGACCAGCCUGGCCAACAUGGCAGAAACCCCAUCUCUACUAAAAAUACCAAAAUUAGCCGGGCAUGGUGGAACACACCUGCAAUCCCAGCUACUCGGGAGGCUGAGGCAAGAGAAUCGCUUGAACCUGGGAGGCAGAAGUUGCAGUGAAACAAGUUGGUGCCAAUGCAUUCCAGCCUGGAUGAUGGAGCGAGACUCUGUCUCAAGAAAAAAAAAACAAAAACAAAAACAGAACUCUGCCUCAUAGCGUCUUUUAAGUUAUACACUGGACCUAUCCUUUCCUCACUGACAGACAUUUUAAAAAUUUUUUGGUAAGGCCUAGUUCAUAUAAAAUGUAAUCCAAGCCAAAAGUUAACAAGAAUAAGGGGAGGAAAGGGGACUCCAAUAGCAGAGAAAGGUAUUUACCUGGGAUAUACACUGCAAGAAAAUCAAAGCUAUAAGAAACGUCCAUGAAUAGUAGCCAUAAGGCAUCAGAGUGAUAAAAUUCCUGUCCCUAGGAGGGAAUAUUGGAGUUUGCCAGAGAAACAGAAUGAGAGAGACAGAGAGGUUUAUUGUAGGAAUUGGCUCAUAUGAUUACGGAGGCUGAGAAGACCCACGAUCUGCCAUCUGCAAGCUGGAGAAUCAGGAAAGCUGGAGGUGUAAUUCAGUCAAGUCCAAUGGCCAGAGAAGCAAGUGUACUGAUAUCCAAGAGCAGGAGAAAAUAGAUGUCCCAGAACAAGCAGAGAGGCUGAUUUUGUCCUUCCUCUGCCUUUUUGUUUCAUAUGGGGCACUGAAUGGACUGAUGCCCAUCCACAUUAGUGAGGGUGGAUCUUCUUUACUCAGUCUACCAGUAGAAAUGUCAAUGACUUCCAGAAACACCCUCACCAACACACGUGGAAAUAAUGUUUUACCAGGUAUCUGGGCAUCCCUUGGUUCACUCAAGUUGACACAAAAUUAACCAUCACAGAAGGAGACUGGCCUUACUCUGAAAUUAGGAAACUAAAGAAGUGACCAGAAUGGAGACUAGGUAGAGACAACUAGUUCUCUACCAAACAUGUACAGUUAUUCGUUGGUAUCUGAAGGGGAUUGGUUCCAGGAACUCUCAGGGAUACCAAAAUCUGCAGGUGCUCAAGUCAUUUAUAUAAAAUAUUACAGUAUUUGCAUAUAACCUUUGCACAUCUUCCAUAUACUUUAAAUCAUCUCUACAUUACUUAUAAUAAUGAAUGUGUAAAUGCUAUGAAAAUAGUUACUACACUAUUGUUUAUUUGUAUUUUUAUUGAAUUGUUUUGGGGUGGGGGGCAGCUGUAUCUUUCUUAGUAAUAGAACCCCUGGUUUUAGCUGGGCACAUGACUGCCCUCAAUAAAGAUUAAAGUACCCCAGCCUUCCUUGAGAUUGUGGCCAUGUGACUGAACUUUAGACAGUGAGAUAUAAGCAGAUAUCUUCUGUGGCAGUGUUAGGAAACUAUUAAAGACAGUAAGAACAUUGCCCUUUGCCUUCUUUUUCCUUUCUUCAUUUUUCUGCCUGGAAUGCAAAUGUGAUGGCUAACACCCUAGCAGCCAUUUUAGAUUAUGAAGAUGAGAGUCACUCCCCAGGAAGGGUGGACCUGAAAGCUGGAUUCUAGAUGUGGAAUGACAAUACCAGCCCUGGACUACCUACCUGUAGGCUGUGUGUGUGUGUGUGUGAUUGACAGAGAGAGAGAGAGAUAGAUACCACAAGUAACACAAAGCAUCAUACCUGGGACUGGGAAGGUUAAUGUUUAAACAUUUUAAAUGUGGCAUUGGUUUGUUGAAGACAGUCAAGCAGUAGGUGCUGCAGGCUUUGUUGAGGCUAGAAAGCUGUUGGUCUUUAUUAGGUGAUGGCAAAACAAUGGAUCACAUUUUCAUGUGCUGUGUCUUGGGAGGCAAAUGAUGAGAAUGUAGGAUUGGGGAAAAUGGUAAGGAAAAUCCAAAAUGUUCAUGUUUUCUAACCCCUUCUUGCCAAUCUUAAAAGAAGGACAAACAGGCUAGAUUAAGCAAGUCUACAGUUACAAUUGGAAGGAAACACAGCCGUACUAAGGAAGUACUCUGUCUGUGGCCUGCAGUCUAGUUUGACUAGGUCCUGUAUUUGAGCUUUGAAAGAGUAAAGAAUACAAGUGCUCGUAUACCCCUGAAGUAGUUACCAGCAGUGACUGCAAGGAGGUAAUCUUAUGGGAUGAAACUAUAACUCUGUAUUAACCAUCAUAUAUAGCAUAUAUGUGUAUAUGUAUGUGUGUGUGUGUAUAUGUGUAUAUAAAUAUAUGUGUGUGUAUAUACACACAUGUACACACCCUACAACCCAGUGAUUUCAAAAAAUUAAACAUUUGUUUAGCUCAUGAAUCUGUGGGUUGGGUGAACAUUUCUAUUGGUCUUGGCUGGGCUCACCUGUACCCAGUCAGCUGCAGGGUCUAGCUCUUCUUAUCUUGGCUGGGAUCUCACACAUGUCUAGGAUCAGCUGCUUUACUAGUCUAGGAUUGUCUUGGCUGAGACAGGUGGACUACUCAGUUCUCCUCCACUGCCUUAUCCUUCAGCUGGCCAGCCCAGAAAUGUUGCCAUGUUUACAGCAUAAGAGCAAGCAAGAAAGAAUAAUAUGCAACCACUUUUCCAAGCCUAAGGUGAAAGGGCGGGCAGAACCUGUGGUGUUAGGAGGCAACUCAUACCAGCCCAUGGGUCUACCGUUUAAUUUUCAGAAAUUUGGCAAGCUGAUUGUUAACACAGCUGUUGUUUAAUUUAUGUACUUGUAAUUAAAUAAUUUACAUUAAAACAAAGAUAAUAGGUACUCAAAA

Taxonomic tree

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Publications